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Published Papers

With FertilitySA continuing to invest significantly into scientific research programs that target better patient outcomes, we are committed to research projects that demonstrate this in practice.

Embryo Health

Paper “Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo”


Can label-free, non-invasive optical imaging by hyperspectral autofluorescence microscopy discern between euploid and aneuploid cells within the inner cell mass (ICM) of the mouse preimplantation embryo?

K.R.D. is supported by a Mid-Career Fellowship from the Hospital Research Foundation (C-MCF-58-2019). This study was funded by the Australian Research Council Centre of Excellence for Nanoscale Biophotonics (CE140100003) and the National Health and Medical Research Council (APP2003786). The authors declare that there is no conflict of interest.


One of the greatest challenges for IVF clinics is identifying which embryos are suitable for transfer back into the patient’s uterus. The current method involves taking a small number of cells from the embryo (a biopsy), then sequencing the DNA to confirm that the embryo has a predicted number of chromosomes. The revolutionary procedure involves shining gentle doses of light upon an embryo and capturing the scattered light that comes back. This reveals the intricacies of its biochemistry, providing insight into the health of the embryo. Co-author Dr Ryan Rose, Fertility SA Director of Research and Innovation said, “the time to pregnancy can be reduced with this new non-invasive IVF procedure.”