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The 'holy grail' of IVF that went wrong

Monash IVF Group’s ‘inaccurate’ genetic test potentially robbed these women of viable embryos

ABC RN
By Rachael Brown for Background Briefing

Full article: https://www.abc.net.au/news/2022-04-23/monash-ivf-group-faulty-genetic-test-class-action-compensation/101005352

Fertility SA is aware the recent publication regarding the testing of embryos, may have caused some concerns.

In the article it explains that a new screening test used to identify embryos with the correct number of chromosomes that was promised to increase the chance of becoming pregnant, has left patients furious with the Repromed/Monash IVF Group, and feeling robbed of their chance to have a child. The new testing introduced by Repromed was non-invasive. It involved taking a small sample from the liquid surrounding the growing embryo to test for DNA, and then determine if the correct number of chromosome were present.

The article quotes a patient who had been directly impacted by the testing. The patient had this test done on her last embryo which was explained as cheaper, with almost the same accuracy rate as the riskier biopsy method. The result of this test suggested the embryo was non-viable, only to receive a letter from Monash IVF in October 2020 informing her the new test was not accurate and her embryo might have been viable after all.

The standard test used in Australia since the 90s, involves taking a small biopsy of cells from the embryo, however this procedure carries a small risk of harm to the embryo.

 

Genetic screening has evolved over time – to provide patients with peace of mind.

“PGT-A is used to screen out embryos with the “wrong” number of chromosomes so that they are not transferred. PGT-A is distinct from tests used to help people reduce their risk of having a child with a known inherited disorder. These include testing for monogenic/single gene defects (PGT-M) and testing for structural chromosomal rearrangements (PGT-SR).

Many studies have also been conducted to evaluate the safety and usefulness of PGT-A.

Fertility SA has chosen to use the testing of embryos for chromosomal number (PGT-A) cautiously. It is used as an adjunct to proven IVF treatment after careful discussion with a patient’s doctor.

We use PGT-A primarily in treatment of those patients that have a history of miscarriage, implantation failure or as an option after several unsuccessful IVF cycles where good quality embryos have been transferred.

It is technology that is not routinely used for all cycles of IVF treatment.

Fertility SA primarily use PGT technology for the diagnosis of single gene disorders such as cystic fibrosis or chromosomal arrangement abnormalities.

With our partner Genea, Fertility SA use of PGT-M/SR in conjunction with IVF treatment, has proven very successful in providing healthy babies to many families.

Commentary provided by

Michael Barry
Scientific Director
Affiliate Lecturer, University of Adelaide

 

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